Free guide from Innate Naturopathic

The EBV Recovery Trio

Three starting points for overcoming EBV, exploring hidden drivers, and supporting recovery.

First, what EBV means

Epstein-Barr virus (EBV) is an opportunistic viral infection that remains in the body after infection. Viral activity can increase after stressors on the body leading to cyclical symptoms and prolonged fatigue.

Step 01

FIND the hidden drivers

Look beyond the virus. Part of overcoming EBV is addressing factors that may affect immune resilience, oxidative stress levels, HPA - axis function, inflammation, and cellular energy. Here are the hidden drivers that need to be considered:

  • Other infections: Lyme disease and coinfections; post-viral illness, including COVID-19; other infections or parasites when clinically indicated.
  • Environmental exposures: water-damaged buildings/mold, mycotoxins, pesticides, other toxins, and heavy metals.
  • Stress and nervous-system strain: chronic stress, trauma, sleep disruption, and HPA-axis dysregulation.
  • Hormone and metabolic health: thyroid function, adrenal/HPA-axis signaling, and sex-hormone changes.
  • Cellular and nutritional foundations: mitochondrial function, oxidative stress, nutrient insufficiency, diet, and blood-sugar balance.
  • Gut, detoxification, and immune function: digestive or microbiome concerns, liver/elimination pathways, and immune dysregulation.
  • Medication and lifestyle contributors: medication effects and other individualized triggers.

Clinical starting point: review history, exposures, symptoms, medications, and relevant tests. Not every person needs every test.

Want to see which labs can help uncover these drivers?

Step 02

ADDRESS the virus

When EBV activity is increased it is important to address the virus, while also calming inflammation.

Botanical medicine that blocks early binding of the virus

Green tea (Camellia sinensis)
Ginkgo biloba
Licorice root (Glycyrrhiza spp.)
Quercetin

Botanical medicine that acts on viral replication-related pathways

Andrographis
Astragalus membranaceus
Cordyceps
Olive leaf
Scutellaria barbata (skullcap)


Higher interventions

Pharmaceuticals: Valacyclovir

IV therapy: High dose vitamin C

EBOO

Step 03

CALM inflammatory pathways

Support the body's response to oxidative stress and inflammatory signaling while treating any confirmed underlying conditions.

Botanicals

Resveratrol
Curcumin
Reishi (Ganoderma lucidum)
Scutellaria baicalensis (Chinese skullcap)
Quercetin

Targeted antioxidants

Curcumin
Glutathione
N-acetylcysteine (NAC)
Quercetin
Resveratrol
Selenium
Vitamin C

Supportive foundations: adequate sleep, individualized pacing, nutrient-dense meals, stress regulation, and addressing confirmed exposures or nutrient deficiencies.

Putting the three together

FIND what is sustaining symptoms → ADDRESS EBV viral activity and hidden drivers → SUPPORT healthier inflammatory and antioxidant responses.

Work with Dr. Holland

If you would like personalized guidance on uncovering hidden drivers and building a plan that fits you, you can work with Dr. Holland.

Cover of The Toxic Trio by Kasey Holland, N.D.

Pre-order The Toxic Trio

Dr. Holland's book connects EBV, Lyme disease, and mold illness into one integrative framework for understanding chronic fatigue in women.

Safety and medical disclaimer

This handout is for educational purposes only. Do not start or combine treatments without review by your licensed clinician.

© 2026 Dr. Kasey Holland, ND. Adapted from The Toxic Trio.